Blue Sulphur Springs, near Smoot (Greenbrier County), was a popular mineral spring resort for about 24 years (1834–1858). In 1834, the owner built a huge three-story brick hotel with 200 rooms, along with cottages and bathhouses. In the 1840s, he started the first mud baths in the United States. Famous visitors included Presidents Andrew Jackson and Martin Van Buren and General Robert E. Lee.

The resort was sold in 1858 to be used as a college. During the Civil War, soldiers from both sides used the buildings, but in 1864, Union troops burned them down.

Today, only the pavilion, which covers the spring, still stands.